Acetic Anhydride → N-(5-Chloro-2-methoxyphenyl)acetamide

HRID 2057572

反応式

HRID 2057572 の反応式
[NH2:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[O:9][CH3:10].[C:11](OC(=O)C)(=[O:13])[CH3:12]>[Zn]>[C:11]([NH:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[O:9][CH3:10])(=[O:13])[CH3:12]

参加物

4

反応物 2

HCID 7918Acetic AnhydrideHCID 667635-Chloro-2-methoxyaniline

生成物 1

HCID 346203N-(5-Chloro-2-methoxyphenyl)acetamide

試薬・触媒・溶媒 1

HCID 23994Zinc触媒

実験手順

0.2 mol (31.5 g) of 2-amino-4-chloroanisole, 40 ml of absolute alcohol, 20 ml of acetic anhydride and a pinch of zinc powder are placed in a 150 ml flask; the solution is brought to reflux for 30 minutes. The reaction liquid is poured onto crushed ice. The product obtained is separated; it is crystallized in a methanol/water mixture (20/80).

後処理

  1. temperatureto reflux for 30 minutes
  2. customThe reaction liquid
  3. additionis poured
  4. customonto crushed ice
  5. customThe product obtained
  6. customis separated
  7. customit is crystallized in a methanol/water mixture (20/80)

出典と根拠

ORDレコード
ord-c42d966b02af44adb9dfab5d9b71aeeb
出典データセット
uspto-grants-1980_07
特許番号
US04211776

関連ノート

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