1-Methylpiperazine → 5,11-dihydro-11-[6-(4-methyl-1-piperazinyl)-caproyl]-6H-pyrido-[2,3-b][1,4]-benzodiazepine-6-one
反応式
Cl[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][C:7]([N:9]1[C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=2[C:13](=[O:20])[NH:12][C:11]2[CH:21]=[CH:22][CH:23]=[N:24][C:10]1=2)=[O:8].[CH3:25][N:26]1[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]1>>[CH3:25][N:26]1[CH2:31][CH2:30][N:29]([CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][C:7]([N:9]2[C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=3[C:13](=[O:20])[NH:12][C:11]3[CH:21]=[CH:22][CH:23]=[N:24][C:10]2=3)=[O:8])[CH2:28][CH2:27]1参加物
3
実験手順
Using the procedure of Example 9, the product of Step A was reacted with 1-methyl-piperazine to obtain a 36% yield of 5,11-dihydro-11-[6-(4-methyl-1-piperazinyl)-caproyl]-6H-pyrido-[2,3-b][1,4]-benzodiazepine-6-one melting at 179°-181° C. after crystallization from ethyl acetate.
出典と根拠
- ORDレコード
- ord-72b22703fc8740f2b6bb72ecd1a5de91
- 出典データセット
- uspto-grants-1980_07
- 特許番号
- US04213985
反応ノート
読み込み中…