Sodium Hydroxide → HCID 12853039、化合物

HRID 2057992ノート

反応式

HRID 2057992 の反応式
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]1[CH2:13][C:12](=[O:14])[CH:11]=[C:10]([CH3:15])[CH:9]1C(OCC)=O.[OH-].[Na+]>C(O)C.O>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]1[CH2:13][C:12](=[O:14])[CH:11]=[C:10]([CH3:15])[CH2:9]1

参加物

5

反応物 2

HCID 14798Sodium HydroxideHCID 12853038HCID 12853038、化合物

生成物 1

HCID 12853039HCID 12853039、化合物収率 98.6%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒

実験手順

To 5-(2-fluorophenyl)-3-methyl-4-carbethoxy-2-cyclohexen-1-one (57.3 g, 0.21 mole) was added a solution of sodium hydroxide (11.5 g, 0.29 mole) in 35 ml of ethanol and 80 ml of water. The stirred reaction mixture was heated under reflux for 8 hours. The ethanol was removed by evaporation under reduced pressure, and the residue was extracted with diethyl ether. The ether extract was dried over sodium sulfate and filtered. The filtrate was evaporated under reduced pressure to give 5-(2-fluorophenyl)-3-methyl-2-cyclohexen-1-one (42.3 g).

後処理

  1. customThe stirred reaction mixture
  2. temperaturewas heated
  3. temperatureunder reflux for 8 hours
  4. customThe ethanol was removed by evaporation under reduced pressure
  5. extractionthe residue was extracted with diethyl ether
  6. extractionThe ether extract
  7. dry with materialwas dried over sodium sulfate
  8. filtrationfiltered
  9. customThe filtrate was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-b864f76a026444069879d65c5def32a5
出典データセット
uspto-grants-1980_07
特許番号
US04214004

反応ノート

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