N-bromobutanimide → Ethyl 2-(4-bromomethylphenoxy)-2-methylpropionate

HRID 2058075ノート

反応式

HRID 2058075 の反応式
[C:1]1([CH3:16])[CH:6]=[CH:5][C:4]([O:7][C:8]([CH3:15])([CH3:14])[C:9]([O:11][CH2:12][CH3:13])=[O:10])=[CH:3][CH:2]=1.[Br:17]N1C(=O)CCC1=O>C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1.C(Cl)(Cl)(Cl)Cl>[Br:17][CH2:16][C:1]1[CH:6]=[CH:5][C:4]([O:7][C:8]([CH3:15])([CH3:14])[C:9]([O:11][CH2:12][CH3:13])=[O:10])=[CH:3][CH:2]=1

参加物

5

反応物 2

HCID 67184N-bromobutanimideHCID 1531788Ethyl 2-methyl-2-(4-methylphenoxy)propanoate

生成物 1

HCID 12870372Ethyl 2-(4-bromomethylphenoxy)-2-methylpropionate収率 67.5%

試薬・触媒・溶媒 2

HCID 7187Benzoyl Peroxide触媒HCID 5943Carbon Tetrachloride溶媒

実験手順

(a) A mixture of 20 g of ethyl 2-(p-tolyloxy)-2-methylpropionate, 17.7 g of N-bromosuccinimide, 0.2 g of benzoyl peroxide and 140 ml of anhydrous carbon tetrachloride is refluxed under heating for 4 hours. After the reaction, the reaction mixture is left to stand for cooling and washed with water. The carbon tetrachloride layer is dried and then concentrated. The resulting oily product (28 g) is distilled under reduced pressure to give 18.3 g of ethyl 2-(4-bromomethylphenoxy)-2-methylpropionate, bp 146° to 148° C./1-2 mmHg.

後処理

  1. temperatureis refluxed
  2. temperatureunder heating for 4 hours
  3. customAfter the reaction
  4. waitthe reaction mixture is left
  5. temperaturefor cooling
  6. washwashed with water
  7. dry with materialThe carbon tetrachloride layer is dried
  8. concentrationconcentrated
  9. distillationThe resulting oily product (28 g) is distilled under reduced pressure

出典と根拠

ORDレコード
ord-ec106db9c730455e99d7402e9f187a82
出典データセット
uspto-grants-1980_07
特許番号
US04214094

反応ノート

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