Sodium Hydroxide → Sodium 2-[4-(4-chloroanilinomethyl)-2-hydroxyphenoxy]-2-methylpropionate
反応式
[CH3:1][C:2]1([CH3:22])[C:7](=[O:8])[O:6][C:5]2[CH:9]=[C:10]([CH2:13][NH:14][C:15]3[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][CH:16]=3)[CH:11]=[CH:12][C:4]=2[O:3]1.[OH-:23].[Na+:24]>C(O)C>[Cl:21][C:18]1[CH:19]=[CH:20][C:15]([NH:14][CH2:13][C:10]2[CH:11]=[CH:12][C:4]([O:3][C:2]([CH3:22])([CH3:1])[C:7]([O-:6])=[O:8])=[C:5]([OH:23])[CH:9]=2)=[CH:16][CH:17]=1.[Na+:24]参加物
4
実験手順
To a solution of 158.7 mg of 3,3-dimethyl-7-(4-chloroanilinomethyl)-1,4-benzodioxan-2-one in 10 ml of ethanol is added 5 ml of a 1/10 N sodium hydroxide aqueous solution and the mixture is warmed to give clear solution. The solution is concentrated and the precipitated crystals are collected by filtration, washed with water and ether, and dried to give 140 mg of sodium 2-[4-(4-chloroanilinomethyl)-2-hydroxyphenoxy]-2-methylpropionate, mp 121° to 125° C.