3-Bromo-4-[(2-aminoethyl)thiomethyl]pyridine → HCID 178512223、化合物
反応式
BrC1C=NC=CC=1CSCCN.C([NH:21][C:22]([NH:35][CH2:36][CH2:37][S:38][CH2:39][C:40]1[C:45]([Br:46])=[CH:44][CH:43]=[CH:42][N:41]=1)=[N:23][CH2:24][CH2:25][S:26][CH2:27][C:28]1[C:33]([Br:34])=[CH:32][CH:31]=[CH:30][N:29]=1)(=O)C1C=CC=CC=1>N1C=CC=CC=1>[Br:46][C:45]1[C:40]([CH2:39][S:38][CH2:37][CH2:36][NH:35][C:22]([NH:23][CH2:24][CH2:25][S:26][CH2:27][C:28]2[C:33]([Br:34])=[CH:32][CH:31]=[CH:30][N:29]=2)=[NH:21])=[N:41][CH:42]=[CH:43][CH:44]=1参加物
4
実験手順
The reaction of 3-bromo-4-[(2-aminoethyl)thiomethyl]pyridine with N-benzoyl-bis-dimethylthioimidocarbonate in pyridine by the method described in Example 12 yielded N-benzoyl-N',N"-bis-[2-((3-bromo-2-pyridyl)methylthio)ethyl]guanidine which, on acid hydrolysis, yielded the title compound.