Sulfuric Acid → 1,3-dimethyl-4-nitro-1H-pyrazole-5-carboxamide

HRID 2058610

反応式

HRID 2058610 の反応式
[CH3:1][N:2]1[C:6]([C:7]#[N:8])=[C:5]([N+:9]([O-:11])=[O:10])[C:4]([CH3:12])=[N:3]1.S(=O)(=O)(O)[OH:14]>O>[CH3:1][N:2]1[C:6]([C:7]([NH2:8])=[O:14])=[C:5]([N+:9]([O-:11])=[O:10])[C:4]([CH3:12])=[N:3]1

参加物

4

反応物 2

HCID 1118Sulfuric AcidHCID 965071,3-dimethyl-4-nitro-1H-pyrazole-5-carbonitrile

生成物 1

HCID 12297641,3-dimethyl-4-nitro-1H-pyrazole-5-carboxamide

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

27.2 g of 1,3-dimethyl-4-nitropyrazole-5-carbonitrile and 65 ml of concentrated sulfuric acid are stirred at 80° C. for 6 hours. The mixture is poured into 700 g of ice and water, and the precipitate is filtered off and suspended in ice-water; the suspension is neutralized with sodium bicarbonate to yield 27.3 g of 1,3-dimethyl-4-nitropyrazole-5-carboxamide, mp 164° to 165° C.

後処理

  1. filtrationthe precipitate is filtered off

出典と根拠

ORDレコード
ord-58589026adbf4087aa1210eba6aabe36
出典データセット
uspto-grants-1982_03
特許番号
US04317823

関連ノート

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