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反応

Water → 1-Methyl-N3-[5-hydroxypentyl]-N5-[3-[3-[(dimethylamino) methyl]phenoxy]propyl]-1H-1,2,4-triazole-3,5-diamine

HRID 2058731

印刷プレビュー

反応式

HRID 2058731 の反応式

[CH3:1][N:2]1[C:6]([NH:7][CH2:8][CH2:9][CH2:10][O:11][C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([CH2:18][N:19]([CH3:21])[CH3:20])[CH:13]=2)=[N:5][C:4]([NH2:22])=[N:3]1.[OH:23][CH2:24][CH2:25][CH2:26][CH2:27][CH:28]=O.[BH4-].[Na+].O>C(O)C>[CH3:1][N:2]1[C:6]([NH:7][CH2:8][CH2:9][CH2:10][O:11][C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([CH2:18][N:19]([CH3:21])[CH3:20])[CH:13]=2)=[N:5][C:4]([NH:22][CH2:28][CH2:27][CH2:26][CH2:25][CH2:24][OH:23])=[N:3]1

参加物実験手順後処理出典と根拠反応ノート

参加物

6

反応物 4

HCID 202055-Hydroxypentanal

HCID 4311764Sodium borohydride

HCID 137898531-Methyl-N5-[3-[3-[(dimethylamino)methyl]phenoxy]propyl]-1H-1,2,4-triazole-3,5-diamine

生成物 1

HCID 543486491-Methyl-N3-[5-hydroxypentyl]-N5-[3-[3-[(dimethylamino) methyl]phenoxy]propyl]-1H-1,2,4-triazole-3,5-diamine

試薬・触媒・溶媒 1

HCID 702

Ethanol

溶媒

実験手順

1-Methyl-N5 -[3-[3-[(dimethylamino)methyl]phenoxy]propyl]-1H-1,2,4-triazole-3,5-diamine (1.0 g) and 5-hydroxypentanal (1.9 ml) were heated at reflux in ethanol (30 ml) for 5 h. The solution was cooled at 5° and treated with sodium borohydride (0.76 g). The resulting suspension was stirred at room temperature for 16 h, treated with water and reduced in volume in vacuo. The aqueous solution was extracted with ethyl acetate, and the organic extracts were distilled to give the title compound as a pale yellow oil (0.47 g) b.p. 250°/0.5 mm. TLC silica; ethyl acetate:isopropanol:water: 0.88 ammonia 25:15:8:2, Rf 0.6.

後処理

temperatureThe solution was cooled at 5°
extractionThe aqueous solution was extracted with ethyl acetate
distillationthe organic extracts were distilled

出典と根拠

ORDレコード: ord-cb7752d425f14d82958ce3923fd45f6f
出典データセット: uspto-grants-1982_03
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04318913

反応ノート

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