Chloroacetyl chloride → HCID 13021162、化合物

HRID 2058940

反応式

HRID 2058940 の反応式
[CH3:1][C:2]1([CH3:9])[CH2:6][CH:5]([CH3:7])[CH2:4][C:3]1=O.CC1CC(C)(C)CC1=O.S([O-])([O-])(=O)=O.[NH4+].[NH4+].C(N)C=C.ClCC(Cl)=O.C(N(CC)CC)C.C[C:43]1(C)CC(C)[C:45]([N:49](CC=C)[C:50](=[O:53])[CH2:51][Cl:52])=[CH:44]1.CC1CC(C)(C)C(N(CC=C)C(=O)CCl)=C1>C1C=CC=CC=1>[CH3:7][C:5]1[CH2:6][C:2]([CH3:9])([CH3:1])[CH2:3][C:4]=1[N:49]([CH2:45][CH:44]=[CH2:43])[C:50](=[O:53])[CH2:51][Cl:52]

参加物

10

反応物 8

HCID 6577Chloroacetyl chlorideHCID 7853AllylamineHCID 8471TriethylamineHCID 1073242,4,4-TrimethylcyclopentanoneHCID 1196322,2,4-TrimethylcyclopentanoneHCID 6097028Ammonium SulfateHCID 13021160HCID 13021160、化合物HCID 13021161HCID 13021161、化合物

生成物 1

HCID 13021162HCID 13021162、化合物

試薬・触媒・溶媒 1

HCID 241Benzene溶媒3 回

実験手順

By the same procedure as in Example 63 using a mixture comprising 2,2,4-trimethylcyclopentanone and 2,4,4-trimethylcyclopentanone (about 1:1) (25.2 parts by weight; 0.2 mole) in 0.2 liter of benzene, 0.1 part by weight of ammonium sulfate, and 11.4 parts by weight (0.2 mole) of allylamine, further reacted with 22.6 parts by weight (0.2 mole) of chloracetyl chloride in 0.05 liter of benzene and 22 parts by weight (0.2 mole) of triethylamine in 0.1 liter of benzene, a mixture of isomers consisting of N-(3,3,5-trimethylcyclopenten-1-yl)-N-allyl-α-chloroacetamide, N-(3,5,5-trimethylcyclopenten-1-yl)-N-allyl-α-chloroacetamide, and N-(2,4,4-trimethylcyclopenten-1-yl)-N-allyl-α-chloroacetamide was obtained. The yield of brown oily distillate (B.P.=88°-93° C. at 1.0 torr) having a refractive index (nD20 =1.4978) was 29 parts by weight. The content of organically combined chlorine was 15.9% (14.7%). The nitrogen content was 6.1% (5.8%).

後処理

  1. additiona mixture of isomers

出典と根拠

ORDレコード
ord-dca8fee64b6548ecab7c62a651f09001
出典データセット
uspto-grants-1982_03
特許番号
US04319918

関連ノート

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