Acetamide → N'-Phenyl-N,N-dimethyl-acetamidine

反応式

[CH3:1][N:2]([CH3:6])[C:3](=O)[CH3:4].C(N)(=O)C1C=CC=CC=1.[NH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1.C(N)(=O)C>C1C=CC=CC=1>[CH3:1][N:2]([CH3:6])[C:3](=[N:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[CH3:4]

参加物

実験手順

The conventional procedure of Example 1 was repeated except that 32.7 g (0.375 mole) of N,N-dimethylacetamide was substituted for the benzamide and a solution of 11.6 g aniline in 50 ml of benzene was utilized. Workup as in Example 1 yielded N,N-dimethyl-N-phenylacetamidine in form of a colorless oil, b.p. 73° C. at 0.12 mm of mercury in only 53% yield based on aniline or 49% yield based on POCl3 and a meager 19.5% yield based on the acetamide.