Dimethylamine → N,N-Dimethyl-N'-phenyl-benzamidine

HRID 2059004

反応式

HRID 2059004 の反応式
[C:1]([NH:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)(=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.S(Cl)(Cl)=O.[CH3:20][NH:21][CH3:22]>C(Cl)Cl>[CH3:20][N:21]([CH3:22])[C:1](=[N:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 674DimethylamineHCID 7168BenzanilideHCID 24386Thionyl Chloride

生成物 1

HCID 351862N,N-Dimethyl-N'-phenyl-benzamidine収率 83%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

Into a slurry of 19.7 g of benzanilide (m.p. 162°-164° C.) in 200 ml of methylene chloride was added a solution of 12.0 g of thionylchloride in 50 ml of methylene chloride. After the addition was completed and the reaction mixture was stirred for one hour at room temperature, gaseous dimethylamine was introduced until the solution became saturated. Workup by filtration, waterwash, removal of the solvent and distillation afforded N,N-dimethyl-N'-phenylbenzamidine in 18.6 g or 83% yield.

後処理

  1. additionAfter the addition
  2. filtrationWorkup by filtration, waterwash, removal of the solvent and distillation

出典と根拠

ORDレコード
ord-10df2198bc5e4c8187b258816a5af1ba
出典データセット
uspto-grants-1982_03
特許番号
US04321202

関連ノート

読み込み中…