化工社化工社 化学情報印刷レポート · 研究参考用
Hydroxyamine hydrochloride → 3-(3-(Trifluoromethyl)phenyl)-1,2-oxazol-5-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydroxyamine hydrochloride | HCID 443297 | — |
| 反応物 | Sodium Acetate | HCID 517045 | — |
| 反応物 | 3-(Trifluoromethyl)benzoylacetonitrile | HCID 520304 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 3-(3-(Trifluoromethyl)phenyl)-1,2-oxazol-5-amine | HCID 13035544 | — |
反応手順
3-(Trifluoromethyl)benzoylacetonitrile (3.8 grams) and 125 ml. ethanol were placed in a 500 ml. flask. The solution was treated with sodium acetate (12 grams) and hydroxylamine.hydrochloride (9 grams in 125 ml. water) and then heated to reflux for two hours. After cooling to room temperature, the ethanol was removed and the residue extracted with ether. The ether extracts were then washed with water, brine, and dried with MgSO4. The solid residue obtained was recrystallized from an ethanol/water solution, m.p. 89°-90° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04322429 |
| 出典データセット | uspto-grants-1982_03 |
| ORD ID | ord-7523057963bb400c8ce725c409847f9a |
| 出典メモ | uspto-grants-1982_03 |