反应详情

3-(Trifluoromethyl)benzoylacetonitrile (3.8 grams) and 125 ml. ethanol were placed in a 500 ml. flask. The solution was treated with sodium acetate (12 grams) and hydroxylamine.hydrochloride (9 grams in 125 ml. water) and then heated to reflux for two hours. After cooling to room temperature, the ethanol was removed and the residue extracted with ether. The ether extracts were then washed with water, brine, and dried with MgSO4. The solid residue obtained was recrystallized from an ethanol/water solution, m.p. 89°-90° C.

1. temperatureheated
2. temperatureto reflux for two hours
3. customthe ethanol was removed
4. extractionthe residue extracted with ether
5. washThe ether extracts were then washed with water, brine
6. dry with materialdried with MgSO4
7. customThe solid residue obtained
8. customwas recrystallized from an ethanol/water solution, m.p. 89°-90° C.