2,6-Dimethoxybenzoyl chloride → 2,6-Dimethoxy-N-(4-(4-(trifluoromethyl)phenyl)-5-isoxazolyl)benzamide

HRID 2059233

反応式

HRID 2059233 の反応式
[F:1][C:2]([F:16])([F:15])[C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:10]=[N:11][O:12][C:13]=2[NH2:14])=[CH:5][CH:4]=1.[CH3:17][O:18][C:19]1[CH:27]=[CH:26][CH:25]=[C:24]([O:28][CH3:29])[C:20]=1[C:21](Cl)=[O:22]>C1(C)C=CC=CC=1>[CH3:29][O:28][C:24]1[CH:25]=[CH:26][CH:27]=[C:19]([O:18][CH3:17])[C:20]=1[C:21]([NH:14][C:13]1[O:12][N:11]=[CH:10][C:9]=1[C:6]1[CH:5]=[CH:4][C:3]([C:2]([F:1])([F:15])[F:16])=[CH:8][CH:7]=1)=[O:22]

参加物

4

反応物 2

HCID 748102,6-Dimethoxybenzoyl chlorideHCID 205467404-(4-(Trifluoromethyl)phenyl)-5-aminoisoxazole

生成物 1

HCID 130355642,6-Dimethoxy-N-(4-(4-(trifluoromethyl)phenyl)-5-isoxazolyl)benzamide

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

4-(4-(Trifluoromethyl)phenyl)-5-aminoisoxazole (1.0 g) and 2,6-dimethoxybenzoylchloride (2 g) were refluxed in 100 ml. toluene for 3 hours. The reaction mixture was cooled and the final product was then collected and recrystallized from ethanol, m.p. 199°-201° C.

後処理

  1. temperatureThe reaction mixture was cooled
  2. customthe final product was then collected
  3. customrecrystallized from ethanol, m.p. 199°-201° C.

出典と根拠

ORDレコード
ord-680c61f813ff4726bed668b4b9331c3a
出典データセット
uspto-grants-1982_03
特許番号
US04322429

関連ノート

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