3-Methoxy-3-oxopropanoic acid → HCID 178500105、化合物

HRID 2059477ノート

反応式

HRID 2059477 の反応式
COC(=O)CC(=O)O.COc1ccc2c(c1)c(CC=O)c(C)n2C(=O)c1ccc(Cl)cc1>NCc1ccccc1.O=C(O)C(F)(F)F.CN(C)c1ccncc1.C1CCOC1>COC(=O)/C=C/Cc1c(C)n(C(=O)c2ccc(Cl)cc2)c2ccc(OC)cc12

参加物

6

反応物 2

HCID 5383663-Methoxy-3-oxopropanoic acidHCID 20158193[1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetaldehyde

生成物 1

HCID 178500105HCID 178500105、化合物収率 0%

試薬・触媒・溶媒 3

HCID 142844-(Dimethylamino)pyridine試薬HCID 12484433Benzenemethanamine, trifluoroacetate触媒HCID 8028Tetrahydrofuran溶媒

反応条件

温度
25 °C

後処理

  1. temperatureThe product mixture was cooled to 25 °C.
  2. filtrationFiltered through a pad of celite · Organic 相を保持
  3. wash"The celite was washed with ethyl acetate (3 x 1 mL)."
  4. concentrationThe filtrate was concentrated under reduced pressure
  5. additionA 0.07 M stock solution of the internal standard ethylene carbonate (0.70 mL in CDCl3) was added.

出典と根拠

ORDレコード
ord-ba527f1b96ab4c10895133b2db7f3c76
出典データセット
Transfer learning optimization of 26 decarboxylative olefination reactions

反応ノート

読み込み中…