Methanol → Methyl 2-(piperidin-2-yl)acetate hydrochloride

HRID 2059895ノート

反応式

HRID 2059895 の反応式
S(Cl)([Cl:3])=O.C(OC([N:12]1[CH2:17][CH2:16][CH2:15][CH2:14][CH:13]1[CH2:18][C:19]([OH:21])=[O:20])=O)(C)(C)C.[CH3:22]O>>[ClH:3].[NH:12]1[CH2:17][CH2:16][CH2:15][CH2:14][CH:13]1[CH2:18][C:19]([O:21][CH3:22])=[O:20]

参加物

4

反応物 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 50585361-Boc-2-Piperidineacetic Acid

生成物 1

HCID 13778732Methyl 2-(piperidin-2-yl)acetate hydrochloride収率 90%

実験手順

Thionyl chloride (5.5 ml, 75 mmol) was added to a solution of 2-carboxymethylpiperidine-1-carboxylic acid tert-butyl ester (6 g, 25 mmol) in methanol (60 ml) while stirring and the mixture was then refluxed for 16 h. The solvent was removed under vacuum and the crude product used in the next stage without purification. Yield: 90%

後処理

  1. temperaturethe mixture was then refluxed for 16 h
  2. customThe solvent was removed under vacuum
  3. customthe crude product used in the next stage without purification

出典と根拠

ORDレコード
ord-86ecdd5a9d034b609630e1d9a6c6bff5
出典データセット
uspto-grants-2012_10
特許番号
US08278319B2

反応ノート

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