Potassium tert-butoxide → HCID 67315804、化合物

HRID 2059919ノート

反応式

HRID 2059919 の反応式
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][C:11]([CH2:20][CH2:21][C:22](OC)=[O:23])([CH2:14][CH2:15][C:16]([O:18][CH3:19])=[O:17])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].CC([O-])(C)C.[K+]>C1COCC1>[O:23]=[C:22]1[CH2:21][CH2:20][C:11]2([CH2:10][CH2:9][N:8]([C:6]([O:5][C:1]([CH3:4])([CH3:2])[CH3:3])=[O:7])[CH2:13][CH2:12]2)[CH2:14][CH:15]1[C:16]([O:18][CH3:19])=[O:17]

参加物

4

反応物 2

HCID 23665647Potassium tert-butoxideHCID 86641304HCID 86641304、化合物

生成物 1

HCID 67315804HCID 67315804、化合物収率 78%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

Dimethyl 3,3′-(1-(tert-butoxycarbonyl)piperidine-4,4-diyl)dipropanoate (600 mg, 1.68 mmol) was dissolved in dry THF (10 ml) and a solution of t-BuOK (417 mg, 3.6 mmol) in THF was added at ice cold reaction conditions. The reaction mixture was stirred at room temperature for 2 h. TLC revealed completion of the reaction. The solvent was evaporated to dryness, the residue diluted with ethyl acetate and washed with water and brine. The organic layer was dried over Na2SO4, concentrated to dryness and purified by column chromatography to obtain the desired compound. Yield: 78%

後処理

  1. customcompletion of the reaction
  2. customThe solvent was evaporated to dryness
  3. additionthe residue diluted with ethyl acetate
  4. washwashed with water and brine
  5. dry with materialThe organic layer was dried over Na2SO4
  6. concentrationconcentrated to dryness
  7. custompurified by column chromatography

出典と根拠

ORDレコード
ord-1bacfae85dca4f8eab36f9ae392dc763
出典データセット
uspto-grants-2012_10
特許番号
US08278319B2

反応ノート

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