Sodium Hydroxide → Bupivacaine (USAN:INN:BAN)

HRID 2059964

反応式

HRID 2059964 の反応式
[CH3:1][CH2:2][CH2:3][CH2:4][N:5]1[CH:10]([C:11]([NH:13][C:14]2[C:15]([CH3:21])=[CH:16][CH:17]=[CH:18][C:19]=2[CH3:20])=[O:12])[CH2:9][CH2:8][CH2:7][CH2:6]1.Cl.[OH-].[Na+]>O>[CH3:1][CH2:2][CH2:3][CH2:4][N:5]1[CH:10]([C:11]([NH:13][C:14]2[C:15]([CH3:21])=[CH:16][CH:17]=[CH:18][C:19]=2[CH3:20])=[O:12])[CH2:9][CH2:8][CH2:7][CH2:6]1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 64737Bupivacaine Hydrochloride

生成物 1

HCID 2474Bupivacaine (USAN:INN:BAN)

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

Bupivacaine hydrochloride (Sigma-Aldrich Corporation, St. Louis, Mo.) was dissolved in de-ionized (DI) water at a concentration of 40 mg/ml (saturation). A calculated amount of sodium hydroxide (1 N solution) was added to the solution and the pH of the final mixtures was adjusted to 10 to precipitate the BP bate. The precipitated product was filtered, and further washed with DI water for at least three times. The precipitated product was dried at approximately 40° C. in vacuum for 24 h.

後処理

  1. customto precipitate the BP bate
  2. filtrationThe precipitated product was filtered
  3. washfurther washed with DI water for at least three times
  4. customThe precipitated product was dried at approximately 40° C. in vacuum for 24 h.

出典と根拠

ORDレコード
ord-bbe0ae0487d0453db13663838e0d921d
出典データセット
uspto-grants-2012_10
特許番号
US08278330B2

関連ノート

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