Nitric Acid → 2,3-Difluoro-4-methyl-6-nitrophenol

HRID 2060002

反応式

HRID 2060002 の反応式
[F:1][C:2]1[C:7]([F:8])=[C:6]([CH3:9])[CH:5]=[CH:4][C:3]=1[OH:10].[N+:11]([O-])([OH:13])=[O:12]>ClCCl>[F:1][C:2]1[C:7]([F:8])=[C:6]([CH3:9])[CH:5]=[C:4]([N+:11]([O-:13])=[O:12])[C:3]=1[OH:10]

参加物

4

反応物 2

HCID 944Nitric AcidHCID 27741512,3-Difluoro-4-methylphenol

生成物 1

HCID 594441602,3-Difluoro-4-methyl-6-nitrophenol収率 91.5%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To 2,3-difluoro-4-methylphenol (1 g, 6.94 mmol) in dichloromethane at 0° C. was added nitric acid 70% (0.7 mL, 7.77 mmol). After 1 h at room temperature the solution was washed with water, dried and evaporated to give 2,3-difluoro-4-methyl-6-nitrophenol (1.2 g, 6.35 mmol, 91% yield) (D44) as yellow solid.

後処理

  1. washAfter 1 h at room temperature the solution was washed with water
  2. customdried
  3. customevaporated

出典と根拠

ORDレコード
ord-f01ef939869748058f52799a79c00349
出典データセット
uspto-grants-2012_10
特許番号
US08278328B2

関連ノート

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