Hydrochloric Acid → 4-(2-Methoxyethoxy)cyclohexanone
反応式
[CH3:1][O:2][CH2:3][CH2:4][O:5][CH:6]1[CH2:15][CH2:14][C:9]2(OCC[O:10]2)[CH2:8][CH2:7]1.Cl>C1COCC1>[CH3:1][O:2][CH2:3][CH2:4][O:5][CH:6]1[CH2:15][CH2:14][C:9](=[O:10])[CH2:8][CH2:7]1参加物
4
実験手順
8-{[2-(Methyloxy)ethyl]oxy}-1,4-dioxaspiro[4.5]decane (D60) (1.6 g, 7 mmol), was dissolved in 20 mL of THF and HCl (25 eq., 5M, 35 mL) was added at Rt. The mixture was stirred at Rt for 5 hr. THF was then evaporated and the aqueous was extracted with dichloromethane (2×). Organics were washed once with water, dried over Na2SO4, filtered and the solvent was evaporated to afford the title compound, 1.3 g, complete conversion as a pale yellow oil.
後処理
- customTHF was then evaporated
- extractionthe aqueous was extracted with dichloromethane (2×)
- washOrganics were washed once with water
- dry with materialdried over Na2SO4
- filtrationfiltered
- customthe solvent was evaporated
出典と根拠
- ORDレコード
- ord-5335ae7c8f6d41f4b8a5e9baf7e1a6a4
- 出典データセット
- uspto-grants-2012_10
- 特許番号
- US08278328B2
反応ノート
読み込み中…