Nitric Acid → 2-Fluoro-4-methyl-6-nitrophenol

HRID 2060033ノート

反応式

HRID 2060033 の反応式
[F:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[OH:9].[N+:10]([O-])([OH:12])=[O:11]>ClCCl>[F:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[C:4]([N+:10]([O-:12])=[O:11])[C:3]=1[OH:9]

参加物

4

反応物 2

HCID 944Nitric AcidHCID 27784852-Fluoro-4-methylphenol

生成物 1

HCID 227538152-Fluoro-4-methyl-6-nitrophenol収率 93%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

2-Fluoro-4-methylphenol (2.6 g, 20.61 mmol) was dissolved in dichloromethane (DCM) and placed in a 100 mL RB flask. Nitric acid, 70% (1.576 mL, 24.74 mmol) was added dropwise (exotherm observed). The reaction mixture was left to stir for ˜1 hr, washed with water, the organic dried and evaporated to give a yellow solid, 2-fluoro-4-methyl-6-nitrophenol (3.276 g, 19.14 mmol, 93% yield).

後処理

  1. customplaced in a 100 mL RB flask
  2. waitThe reaction mixture was left
  3. washwashed with water
  4. customthe organic dried
  5. customevaporated

出典と根拠

ORDレコード
ord-a891407c02384ea4a315a3b378075be7
出典データセット
uspto-grants-2012_10
特許番号
US08278328B2

反応ノート

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