4-Methyl-2-nitrobenzoic acid → (4-Methyl-2-nitrophenyl)methanol

HRID 2060050

反応式

HRID 2060050 の反応式
[CH3:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](O)=[O:7])=[C:4]([N+:11]([O-:13])=[O:12])[CH:3]=1>O1CCCC1>[CH3:1][C:2]1[CH:10]=[CH:9][C:5]([CH2:6][OH:7])=[C:4]([N+:11]([O-:13])=[O:12])[CH:3]=1

参加物

3

反応物 1

HCID 2550274-Methyl-2-nitrobenzoic acid

生成物 1

HCID 53405041(4-Methyl-2-nitrophenyl)methanol収率 98%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a stirred solution of 4-methyl-2-nitrobenzoic acid (5 g, 27.6 mmol) in tetrahydrofuran (THF) (27 mL) was added borane tetrahydrofuran complex (35.9 mL, 35.9 mmol) and the mixture stirred at reflux for 3 hours. After cooling, the reaction mixture was extracted with water and DCM. The combined organic layers were dried over MgSO4 and then evaporated to dryness to give the alcohol (D139) as a pale yellow solid (4.52 g, 98%) which was used without further purification.

後処理

  1. temperatureat reflux for 3 hours
  2. temperatureAfter cooling
  3. extractionthe reaction mixture was extracted with water and DCM
  4. dry with materialThe combined organic layers were dried over MgSO4
  5. customevaporated to dryness

出典と根拠

ORDレコード
ord-199e3ed29ba74c329d60617fec0f9f74
出典データセット
uspto-grants-2012_10
特許番号
US08278328B2

関連ノート

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