Sodium Hydroxide → HCID 68802039、化合物

HRID 2060071ノート

反応式

HRID 2060071 の反応式
Cl.[CH3:2][N:3]([CH2:5][CH:6]1[CH2:14][C:13]2[C:8](=[CH:9][CH:10]=[C:11]([O:15][C:16]([F:19])([F:18])[F:17])[CH:12]=2)[C:7]1=[O:20])[CH3:4].[OH-].[Na+]>O>[CH3:4][N:3]([CH2:5][CH:6]1[CH2:14][C:13]2[C:8](=[CH:9][CH:10]=[C:11]([O:15][C:16]([F:19])([F:17])[F:18])[CH:12]=2)[C:7]1=[O:20])[CH3:2]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 694507812-Dimethylaminomethyl-5-trifluoromethoxy-indan-1-one hydrochloride

生成物 1

HCID 68802039HCID 68802039、化合物

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

14 g of the product from step 3 were dissolved in water; the solution was adjusted to pH 12 with 32% sodium hydroxide solution, while cooling with ice, and extracted three times with dichloromethane, and the combined organic phases were dried over magnesium sulfate, filtered and concentrated in vacuo.

後処理

  1. temperaturewhile cooling with ice
  2. extractionextracted three times with dichloromethane
  3. dry with materialthe combined organic phases were dried over magnesium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-778622f470074d93814ea356c2bf25bd
出典データセット
uspto-grants-2012_10
特許番号
US08278338B2

反応ノート

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