2-[4-(Hydroxymethyl)phenyl]propan-2-ol → 4-(2-Hydroxypropan-2-yl)benzaldehyde
反応式
[OH:1][CH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]([OH:12])([CH3:11])[CH3:10])=[CH:5][CH:4]=1>C(OCC)(=O)C.ClCCl.O=[Mn]=O>[OH:12][C:9]([C:6]1[CH:7]=[CH:8][C:3]([CH:2]=[O:1])=[CH:4][CH:5]=1)([CH3:11])[CH3:10]参加物
5
実験手順
2-[4-(Hydroxymethyl)phenyl]propan-2-ol (1.0 g, 6 mmol) was dissolved in the mixture of ethyl acetate (10 mL) and dichloromethane (5 mL). To the solution, MnO2 (2.6 g, 30 mmol) was added, and the mixture was stirred overnight at room temperature. The solid was filtered off and washed with ethyl acetate. The combined organic phases were concentrated to afford the title compound. 1H NMR (400 MHz CDCl3): δ 10.00 (s, 1H), 7.80 (d, 2H), 7.60 (d, 2H), 1.60 (s, 6H).
後処理
- filtrationThe solid was filtered off
- washwashed with ethyl acetate
- concentrationThe combined organic phases were concentrated
出典と根拠
- ORDレコード
- ord-656c0edb794d41698126c70cd4528d6a
- 出典データセット
- uspto-grants-2012_10
- 特許番号
- US08278335B2
反応ノート
読み込み中…