m-Chloroperbenzoic acid → Methyl 2-methylnicotinate 1-oxide

HRID 2060609

反応式

HRID 2060609 の反応式
[CH3:1][C:2]1[C:7]([C:8]([O:10][CH3:11])=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=1.C1C=C(Cl)C=C(C(OO)=[O:20])C=1>C(Cl)Cl>[CH3:1][C:2]1[N+:3]([O-:20])=[CH:4][CH:5]=[CH:6][C:7]=1[C:8]([O:10][CH3:11])=[O:9]

参加物

4

反応物 2

HCID 70297m-Chloroperbenzoic acidHCID 7015327Methyl 2-methylnicotinate

生成物 1

HCID 20163965Methyl 2-methylnicotinate 1-oxide

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Methyl 2-methylpyridine-3-carboxylate (30 g, 198 mmol) was taken up in DCM (420 mL) and mCPBA (48.9 g, 218 mmol) was added. The resulting solution was stirred at room temperature overnight. The reaction mixture was purified directly by flash chromatography (silica, 0-20% MeOH/EtOAc) to afford the title compound as a beige solid. 1H NMR (500 MHz, d6-DMSO) δ 8.45 (d, 1H), 7.64 (d, 1H), 7.38 (t, 1H), 3.86 (s, 3H), 2.54 (s, 3H).

後処理

  1. customThe reaction mixture was purified directly by flash chromatography (silica, 0-20% MeOH/EtOAc)

出典と根拠

ORDレコード
ord-436bf10d20a14af4a037b2488e8b9794
出典データセット
uspto-grants-2012_10
特許番号
US08278335B2

関連ノート

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