Hydrochloric Acid → 2-(Piperidin-1-yl)acetic acid hydrochloride

HRID 2060650

反応式

HRID 2060650 の反応式
[N:1]1([CH2:7][C:8]([O:10]CC)=[O:9])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.O.[ClH:14]>C1(C)C=CC=CC=1>[ClH:14].[N:1]1([CH2:7][C:8]([OH:10])=[O:9])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 6434661-Piperidineacetic acid, ethyl ester

生成物 1

HCID 2010962-(Piperidin-1-yl)acetic acid hydrochloride収率 83%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

Ethyl 2-(piperidin-1-yl)-acetate (5.5 g, 32.2 mmol), water (12 ml) and c HCl (3 ml) were heated under reflux for 20 hours. Volatile components were evaporated under reduced pressure to leave an off white solid. This solid was co-evaporated with toluene (50 ml×3) and dried in vacuo to give an off white powder (Yield 4.8 g, 83%).

後処理

  1. temperatureunder reflux for 20 hours
  2. customVolatile components were evaporated under reduced pressure
  3. customto leave an off white solid
  4. customdried in vacuo

出典と根拠

ORDレコード
ord-d3dc8b9fea3b481caa28aea72c20a86a
出典データセット
uspto-grants-2012_10
特許番号
US08278448B2

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