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Hydrochloric Acid → 2-(Piperidin-1-yl)acetic acid hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Water | HCID 962 | — |
| 反応物 | 1-Piperidineacetic acid, ethyl ester | HCID 643466 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 2-(Piperidin-1-yl)acetic acid hydrochloride | HCID 201096 | 83% |
反応手順
Ethyl 2-(piperidin-1-yl)-acetate (5.5 g, 32.2 mmol), water (12 ml) and c HCl (3 ml) were heated under reflux for 20 hours. Volatile components were evaporated under reduced pressure to leave an off white solid. This solid was co-evaporated with toluene (50 ml×3) and dried in vacuo to give an off white powder (Yield 4.8 g, 83%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08278448B2 |
| 出典データセット | uspto-grants-2012_10 |
| ORD ID | ord-d3dc8b9fea3b481caa28aea72c20a86a |
| 出典メモ | uspto-grants-2012_10 |