反应详情

Ethyl 2-(piperidin-1-yl)-acetate (5.5 g, 32.2 mmol), water (12 ml) and c HCl (3 ml) were heated under reflux for 20 hours. Volatile components were evaporated under reduced pressure to leave an off white solid. This solid was co-evaporated with toluene (50 ml×3) and dried in vacuo to give an off white powder (Yield 4.8 g, 83%).

1. temperatureunder reflux for 20 hours
2. customVolatile components were evaporated under reduced pressure
3. customto leave an off white solid
4. customdried in vacuo