Sodium Hydroxide → Ly-2886721
反応式
Cl.[NH2:2][C:3]1[S:4][CH2:5][C@@H:6]2[CH2:11][O:10][CH2:9][C@:7]2([C:12]2[CH:13]=[C:14]([NH:19][C:20](=[O:28])[C:21]3[CH:26]=[CH:25][C:24]([F:27])=[CH:23][N:22]=3)[CH:15]=[CH:16][C:17]=2[F:18])[N:8]=1.[OH-].[Na+]>O>[NH2:2][C:3]1[S:4][CH2:5][C@@H:6]2[CH2:11][O:10][CH2:9][C@:7]2([C:12]2[CH:13]=[C:14]([NH:19][C:20](=[O:28])[C:21]3[CH:26]=[CH:25][C:24]([F:27])=[CH:23][N:22]=3)[CH:15]=[CH:16][C:17]=2[F:18])[N:8]=1参加物
4
実験手順
To a suspension of N-(3-((4aS,7aS)-2-Amino-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-7a-yl)-4-fluorophenyl)-5-fluoropicolinamide hydrochloride (20 g, 47 mmol) in water (280 mL) at room temperature is added an aqueous solution of 2N sodium hydroxide (1.2 eq, 27 mL). The mixture is stirred for 30 minutes. The suspension is filtered and the solid is washed with water (3×100 mL). The solid is dried under vacuum at 45° C. to give the title compound as a white solid. The resulting solid is purified via the following two methods: