Hydrochloric Acid → 4-(Trifluoromethyl)cyclohexan-1-amine hydrochloride

HRID 2060870ノート

反応式

HRID 2060870 の反応式
C([NH:8][CH:9]1[CH2:14][CH2:13][CH:12]([C:15]([F:18])([F:17])[F:16])[CH2:11][CH2:10]1)C1C=CC=CC=1.[ClH:19]>CO.O1CCOCC1.[Pd]>[ClH:19].[F:16][C:15]([F:17])([F:18])[CH:12]1[CH2:11][CH2:10][CH:9]([NH2:8])[CH2:14][CH2:13]1

参加物

6

反応物 2

HCID 313Hydrochloric AcidHCID 43434579Benzyl(4-trifluoromethylcyclohexyl)amine

生成物 1

HCID 187699224-(Trifluoromethyl)cyclohexan-1-amine hydrochloride

試薬・触媒・溶媒 3

HCID 23938Palladium触媒HCID 887Methanol溶媒HCID 312751,4-Dioxane溶媒

実験手順

A solution of benzyl(4-trifluoromethylcyclohexyl)amine (Preparation 4) (1.48 g, 5.73 mmol) in MeOH (150 mL) was passed through an H-Cube at 100° C. fitted with a 10% Pd/C CatCart and on full H2 mode. The volume was reduced to 50 mL and 4M HCl in dioxane (1.43 mL) was added. The precipitate was filtered, the filtrate collected and the solvent removed in vacuo. The resulting residue was triturated with acetone to give the title compound: δH (CD3OD) 1.41-1.53 (4H, m), 2.03-2.25 (5H, m), 3.07-3.15 (1H, m).

後処理

  1. customwas passed through an H-Cube at 100° C.
  2. additionwas added
  3. filtrationThe precipitate was filtered
  4. customthe filtrate collected
  5. customthe solvent removed in vacuo
  6. customThe resulting residue was triturated with acetone

出典と根拠

ORDレコード
ord-2d9a4257b37e4839b42c5275f1a5e409
出典データセット
uspto-grants-2012_10
特許番号
US08278442B2

反応ノート

読み込み中…