Sodium Carbonate → 7-Methoxybenzo[b]thiophene-4-carbaldehyde
反応式
P(Cl)(Cl)(Cl)=O.[CH3:6][O:7][C:8]1[C:16]2[S:15][CH:14]=[CH:13][C:12]=2[CH:11]=[CH:10][CH:9]=1.[C:17]([O-])([O-])=[O:18].[Na+].[Na+]>CN(C=O)C>[CH3:6][O:7][C:8]1[C:16]2[S:15][CH:14]=[CH:13][C:12]=2[C:11]([CH:17]=[O:18])=[CH:10][CH:9]=1参加物
5
反応条件
- 温度
- 100 °C
実験手順
Phosphorous oxychloride (0.518 g, 17.7 mmol) was added to DMF (1.04 mL) under argon at rt. After 30 min 7-methoxybenzothiophene (0.5 g, 3.04 mmol) was added and the reaction was heated to 100° C. for 3.5 h. The reaction was cooled to rt and poured into a saturated Na2CO3 solution, extracted with ether (100 mL) and the organic phase dried (MgSO4). Solvent was removed in vacuo to give the title compound: RT=3.34 min; m/z (ES+)=193.2 [M+H]+.
後処理
- temperatureThe reaction was cooled to rt
- extractionextracted with ether (100 mL)
- dry with materialthe organic phase dried (MgSO4)
- customSolvent was removed in vacuo
出典と根拠
- ORDレコード
- ord-acb87c1c32f9409b84c5f1e61d38fb0e
- 出典データセット
- uspto-grants-2012_10
- 特許番号
- US08278442B2
反応ノート
読み込み中…