[4-(2-Furyl)phenyl]methanol → 4-(furan-2-yl)benzyl 4-methyl-2-oxo-2H-chromen-7-ylcarbamate

HRID 2061378ノート

反応式

HRID 2061378 の反応式
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[CH:11]=[CH:10][C:9]([CH2:12][OH:13])=[CH:8][CH:7]=1.[N:14]([C:17]1[CH:26]=[C:25]2[C:20]([C:21]([CH3:28])=[CH:22][C:23](=[O:27])[O:24]2)=[CH:19][CH:18]=1)=[C:15]=[O:16]>C1COCC1>[CH3:28][C:21]1[C:20]2[C:25](=[CH:26][C:17]([NH:14][C:15](=[O:16])[O:13][CH2:12][C:9]3[CH:10]=[CH:11][C:6]([C:2]4[O:1][CH:5]=[CH:4][CH:3]=4)=[CH:7][CH:8]=3)=[CH:18][CH:19]=2)[O:24][C:23](=[O:27])[CH:22]=1

参加物

4

反応物 2

HCID 7537506[4-(2-Furyl)phenyl]methanolHCID 583781007-isocyanato-4-methyl-2H-chromen-2-one

生成物 1

HCID 596031594-(furan-2-yl)benzyl 4-methyl-2-oxo-2H-chromen-7-ylcarbamate収率 9.3%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

(4-(Furan-2-yl)phenyl)methanol (100 mg, 0.57 mmol) and 76 (139 mg, 0.69 mmol) were dissolved in THF (10 mL). The resulting mixture was stirred at room temperature for 15 min and then at 80° C. for 1 h. THF was evaporated off in vacuo. The residue was adsorbed on silica and purified by flash chromatography, eluting with CH2Cl2/EtOAc (1:1) to give the target compound (20 mg, 9%) as a white solid. m/z=376.11 (M+H), 751.22 (2M+H).

後処理

  1. waitat 80° C. for 1 h
  2. customTHF was evaporated off in vacuo
  3. custompurified by flash chromatography
  4. washeluting with CH2Cl2/EtOAc (1:1)

出典と根拠

ORDレコード
ord-73ebde5eabfd4b04ab0a7288ffa45a99
出典データセット
uspto-grants-2012_10
特許番号
US08283340B2

反応ノート

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