1,4-Dioxane → 1-Bromo-5-chloro-3-fluoro-2-isocyanatobenzene
反応式
[Br:1][C:2]1[CH:8]=[C:7]([Cl:9])[CH:6]=[C:5]([F:10])[C:3]=1[NH2:4].[C:11](=O)(OC(Cl)(Cl)Cl)[O:12]C(Cl)(Cl)Cl.O1CCOCC1>CO>[Br:1][C:2]1[CH:8]=[C:7]([Cl:9])[CH:6]=[C:5]([F:10])[C:3]=1[N:4]=[C:11]=[O:12]参加物
5
反応条件
- 温度
- 100 °C
実験手順
2-Bromo-4-chloro-6-fluoroaniline (5 mmol, 1.125 g), bis(trichloromethyl) carbonate (1.7 mmol, 0.50 g) and 1,4-dioxane (10 ml) were mixed together and the mixture was heated to 100° C. for 15 minutes; the mixture was then cooled to room temperature and it was filtered. The filtrate was concentrated to afford a mixture of products (2.2 g) containing the title compound, M++MeO=283 (LC-MS run in methanol).
後処理
- temperaturethe mixture was then cooled to room temperature
- filtrationit was filtered
- concentrationThe filtrate was concentrated
- customto afford
出典と根拠
- ORDレコード
- ord-260a82b4583142db8ad40dc55e3ce1fe
- 出典データセット
- uspto-grants-2012_10
- 特許番号
- US08283364B2
反応ノート
読み込み中…