Sulfamide → HCID 11492439、化合物

HRID 2061904ノート

反応式

HRID 2061904 の反応式
[CH3:1][C:2]1[O:3][C:4]2[CH:12]=[CH:11][CH:10]=[CH:9][C:5]=2[C:6]=1[CH:7]=O.[S:13]([NH2:17])([NH2:16])(=[O:15])=[O:14].[BH4-].[Na+]>C(O)C.O>[CH3:1][C:2]1[O:3][C:4]2[CH:12]=[CH:11][CH:10]=[CH:9][C:5]=2[C:6]=1[CH2:7][NH:16][S:13]([NH2:17])(=[O:15])=[O:14]

参加物

6

反応物 3

HCID 82267SulfamideHCID 5944592-Methylbenzofuran-3-carbaldehydeHCID 4311764Sodium borohydride

生成物 1

HCID 11492439HCID 11492439、化合物

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒

実験手順

2-Methylbenzofuran-3-carbaldehyde (0.51 g, 3.18 mmol) was dissolved in anhydrous ethanol (25 mL). Sulfamide (1.5 g, 16 mmol) was added and the mixture was heated to reflux for 4 days. The mixture was cooled to room temperature. Sodium borohydride (0.132 g, 3.50 mmol) was added and the mixture was stirred at room temperature for 24 hours. The reaction was diluted with water (100 mL) and extracted with DCM (3×75 mL). The extracts were concentrated and suspended in a minimal amount of DCM and filtered to yield the title compound as a white solid.

後処理

  1. temperaturethe mixture was heated
  2. temperatureto reflux for 4 days
  3. extractionextracted with DCM (3×75 mL)
  4. concentrationThe extracts were concentrated
  5. filtrationfiltered

出典と根拠

ORDレコード
ord-cdfee2381cee4727a5d5804bb3142b73
出典データセット
uspto-grants-2012_10
特許番号
US08283478B2

反応ノート

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