1-Benzothiophene-3-carbaldehyde → HCID 11999023、化合物

HRID 2061916ノート

反応式

HRID 2061916 の反応式
[C:1]1([CH:7]2[CH2:12][CH2:11][N:10]([S:13]([NH2:16])(=[O:15])=[O:14])[CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[S:17]1[CH:21]=[C:20]([CH:22]=O)[C:19]2[CH:24]=[CH:25][CH:26]=[CH:27][C:18]1=2.[BH4-].[Na+]>C(O)C>[S:17]1[CH:21]=[C:20]([CH2:22][NH:16][S:13]([N:10]2[CH2:9][CH2:8][CH:7]([C:1]3[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=3)[CH2:12][CH2:11]2)(=[O:15])=[O:14])[C:19]2[CH:24]=[CH:25][CH:26]=[CH:27][C:18]1=2

参加物

5

反応物 3

HCID 2273281-Benzothiophene-3-carbaldehydeHCID 4311764Sodium borohydrideHCID 119990221-Piperidinesulfonamide, 4-phenyl-

生成物 1

HCID 11999023HCID 11999023、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
45 °C

実験手順

4-Phenyl-piperidine-1-sulfonic acid amide (1.5 g, 6.24 mmol) was dissolved in ethanol (20 mL). Benzo[b]thiophene-3-carbaldehyde (1.0 g, 6.24 mmol) was then added and the reaction mixture was warmed to 45° C. overnight. The reaction mixture was cooled to room temperature and then treated with sodium borohydride (0.2 g, 5.29 mmol). The reaction was then quenched by addition of 1N HCl. The reaction mixture was stirred overnight. The product precipitated from solution and was removed by vacuum filtration to yield the title compound as a white solid.

後処理

  1. temperatureThe reaction mixture was cooled to room temperature
  2. customThe reaction was then quenched by addition of 1N HCl
  3. customThe product precipitated from solution
  4. customwas removed by vacuum filtration

出典と根拠

ORDレコード
ord-6e44a8b456864583bab24441660ce391
出典データセット
uspto-grants-2012_10
特許番号
US08283478B2

反応ノート

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