Tetrahydrofuran → Tert-butyl 4-[(2,5-difluorophenyl)(hydroxy)methyl]piperidine-1-carboxylate

HRID 206254

反応式

[C:15]([CH3:16])([CH3:17])([CH3:18])[O:19][C:20](=[O:21])[N:22]1[CH2:23][CH2:24][CH:25]([CH:28]=[O:29])[CH2:26][CH2:27]1.[CH2:10]([Li:11])[CH2:12][CH2:13][CH3:14].[F:1][c:2]1[c:3]([Br:9])[cH:4][c:5]([F:8])[cH:6][cH:7]1.[O:30]1[CH2:31][CH2:32][CH2:33][CH2:34]1>>[F:1][c:2]1[c:3]([CH:28]([CH:25]2[CH2:24][CH2:23][N:22]([C:20]([O:19][C:15]([CH3:16])([CH3:17])[CH3:18])=[O:21])[CH2:27][CH2:26]2)[OH:29])[cH:4][c:5]([F:8])[cH:6][cH:7]1