Formaldehyde → HCID 57650371、化合物
反応式
[Cl:1][C:2]1[CH:25]=[CH:24][C:5]([CH2:6][N:7]2[CH:11]=[N:10][N:9]=[C:8]2[C@H:12]2[CH2:16][CH2:15][CH2:14][N:13]2[C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])=[CH:4][CH:3]=1.[CH2:26]=[O:27]>CC1C=CC=CC=1C>[Cl:1][C:2]1[CH:25]=[CH:24][C:5]([CH2:6][N:7]2[C:11]([CH2:26][OH:27])=[N:10][N:9]=[C:8]2[C@H:12]2[CH2:16][CH2:15][CH2:14][N:13]2[C:17]([O:19][C:20]([CH3:21])([CH3:22])[CH3:23])=[O:18])=[CH:4][CH:3]=1参加物
4
反応条件
- 温度
- 125 °C
実験手順
A mixture of Boc-protected triazole from example 3 (7.7 g, 21.221 mmol) and paraformaldehyde (3.23 g, 5 eq.) in 50 mL of o-xylene was heated at 125° C. for 3 h. After cooling, the mixture was filtered over a Celite-fritted funnel and washed with 10 mL of o-xylene. The filtrate was concentrated in vacuo to provide the desired intermediate as a foam (8.45 g, 100%+)