1-Benzyl-4-nitro-1H-pyrazole → 1-benzyl-1H-pyrazol-4-amine
反応式
[CH2:1]([N:8]1[CH:12]=[C:11]([N+:13]([O-])=O)[CH:10]=[N:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>[Pd]>[CH2:1]([N:8]1[CH:12]=[C:11]([NH2:13])[CH:10]=[N:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1参加物
3
実験手順
A mixture of 1-benzyl-4-nitro-1H-pyrazole (33 mg, 0.162 mmol) and 10% Pd/C (10 mg) was stirred under an hydrogen atmosphere at rt for 12 h. The catalyst was filtered off, washed with methanol and the solvent was removed under reduced pressure to give the title compound as dark brown oil (27.4 mg, 97%). MS ISP (m/e): 174.2.3 (100) [(M+H)+].
後処理
- filtrationThe catalyst was filtered off
- washwashed with methanol
- customthe solvent was removed under reduced pressure
出典と根拠
- ORDレコード
- ord-024c1dacb96f4352a4e4a4e26830e55c
- 出典データセット
- uspto-grants-2012_10
- 特許番号
- US08288403B2
反応ノート
読み込み中…