Water → {1-Butyl-4-[1-(1-ethoxy-ethoxy)-2-phenylethyl]cyclohexyl}dimethylamine

HRID 2063722

反応式

HRID 2063722 の反応式
[CH2:1]([Mg]Cl)[CH2:2][CH2:3][CH3:4].[CH3:7][N:8]([CH3:31])[C:9]1(C#N)[CH2:14][CH2:13][CH:12]([CH:15]([O:23][CH:24]([O:26][CH2:27][CH3:28])[CH3:25])[CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH2:11][CH2:10]1.O.[Cl-].[NH4+]>O1CCCC1>[CH2:1]([C:9]1([N:8]([CH3:31])[CH3:7])[CH2:14][CH2:13][CH:12]([CH:15]([O:23][CH:24]([O:26][CH2:27][CH3:28])[CH3:25])[CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH2:11][CH2:10]1)[CH2:2][CH2:3][CH3:4]

参加物

6

反応物 4

HCID 962WaterHCID 25517Ammonium ChlorideHCID 698102431-Dimethylamino-4-[1-(1-ethoxy-ethoxy)-2-phenylethyl]cyclohexanecarbonitrileHCID 178418265HCID 178418265、化合物

生成物 1

HCID 66887575{1-Butyl-4-[1-(1-ethoxy-ethoxy)-2-phenylethyl]cyclohexyl}dimethylamine

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

A 2 M solution of n-butylmagnesium chloride in tetrahydrofuran (4.62 ml, 9.25 mmol) was added dropwise to a solution of 1-dimethylamino-4-[1-(1-ethoxy-ethoxy)-2-phenylethyl]cyclohexanecarbonitrile (1.06 g, 3.1 mmol) in tetrahydrofuran (15 ml), while cooling with ice and under an argon atmosphere. The mixture was stirred at room temperature for 48 h and thereafter water and saturated ammonium chloride solution (10 ml of each) were added. The phases were separated and the aqueous phase was extracted with diethyl ether (3×10 ml). The combined organic phases were dried with sodium sulfate and concentrated i. vac.

後処理

  1. temperaturewhile cooling with ice and under an argon atmosphere
  2. customThe phases were separated
  3. extractionthe aqueous phase was extracted with diethyl ether (3×10 ml)
  4. dry with materialThe combined organic phases were dried with sodium sulfate
  5. concentrationconcentrated i

出典と根拠

ORDレコード
ord-af4c1f81c53c41e9a8a57f3e86eddcf2
出典データセット
uspto-grants-2012_10
特許番号
US08288406B2

関連ノート

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