Dimethylamine → HCID 59262855、化合物

HRID 2063774ノート

反応式

HRID 2063774 の反応式
CS[C:3]1[S:7][C:6]([C:8]#[N:9])=[C:5]2[CH2:10][CH2:11][CH2:12][C:13](=[O:14])[C:4]=12.[CH3:15][NH:16][CH3:17]>C1COCC1>[CH3:15][N:16]([CH3:17])[C:3]1[S:7][C:6]([C:8]#[N:9])=[C:5]2[CH2:10][CH2:11][CH2:12][C:13](=[O:14])[C:4]=12

参加物

4

反応物 2

HCID 674DimethylamineHCID 27787593-(Methylthio)-4-oxo-4,5,6,7-tetrahydro-2-benzothiophene-1-carbonitrile

生成物 1

HCID 59262855HCID 59262855、化合物収率 45%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

A solution of 3-methylsulfanyl-4-oxo-4,5,6,7-tetrahydro-benzo[c]thiophene-1-carbonitrile (0.446 g) and dimethylamine (excess) in THF were heated in a sealed tube at 80° C. for 10 days. Aqueous work up and chromatographic purification afforded 0.2 g of 3-dimethylamino-4-oxo-4,5,6,7-tetrahydro-benzo[c]thiophene-1-carbonitrile (45%).

後処理

  1. customAqueous work up and chromatographic purification

出典と根拠

ORDレコード
ord-9b765534b6724fe9ac67c1c23000f976
出典データセット
uspto-grants-2012_10
特許番号
US08288400B2

反応ノート

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