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Iodine chloride → 5-Chloro-2-iodo-4-(trifluoromethyl)aniline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Iodine chloride | HCID 24640 | — |
| 反応物 | 3-Chloro-4-(trifluoromethyl)aniline | HCID 67962 | — |
| 反応物 | Sodium bicarbonate sodium sulfite | HCID 18470521 | — |
| 反応物 | Sodium Acetate Trihydrate | HCID 23665404 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | 5-Chloro-2-iodo-4-(trifluoromethyl)aniline | HCID 59320558 | — |
反応手順
Iodine monochloride (1.5 g) was added in one portion to a mixture of 3-chloro-4-trifluoromethylaniline (1.7 g), sodium acetate trihydrate (2.2 g), and acetic acid (10 ml) at room temperature. After 30 min aqueous sodium bicarbonate/sodium sulfite was added and the mixture extracted with diethyl ether. The organic phase was dried over Na2SO4, filtered and evaporated. The residue was purified by chromatography (ethyl acetate-hexane) to afford the title compound, 2.2 g.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08288412B2 |
| 出典データセット | uspto-grants-2012_10 |
| ORD ID | ord-b60f57e2e4c145499e75c59bc916ea89 |
| 出典メモ | uspto-grants-2012_10 |