Dimethylformamide → 1-Chloro-4-fluoro-2-methoxy-5-nitrobenzene
反応式
[Cl:1][C:2]1[CH:7]=[C:6]([N+:8]([O-:10])=[O:9])[C:5]([F:11])=[CH:4][C:3]=1[OH:12].[C:13](=O)([O-])[O-].[K+].[K+].IC.CN(C)C=O>C(OCC)C>[Cl:1][C:2]1[CH:7]=[C:6]([N+:8]([O-:10])=[O:9])[C:5]([F:11])=[CH:4][C:3]=1[O:12][CH3:13]参加物
6
実験手順
A mixture of 2-chloro-4-nitro-5-fluorophenol (D41) (450 mg), potassium carbonate (600 mg), iodomethane (1 ml), and dimethylformamide (5 ml) stirred overnight at room temperature then diethyl ether added and the solution washed with water then dried over MgSO4, filtered and evaporated The product was crystallised from hexane to yield the title compound, 350 mg.
後処理
- washthe solution washed with water
- dry with materialthen dried over MgSO4
- filtrationfiltered
- customevaporated The product
- customwas crystallised from hexane
出典と根拠
- ORDレコード
- ord-9d9ac6ba16b54bf49462fd50602d0c42
- 出典データセット
- uspto-grants-2012_10
- 特許番号
- US08288412B2
反応ノート
読み込み中…