Potassium Nitrate → 2-Chloro-4-fluoro-5-nitrobenzaldehyde
反応式
[Cl:1][C:2]1[CH:9]=[C:8]([F:10])[CH:7]=[CH:6][C:3]=1[CH:4]=[O:5].[N+:11]([O-])([O-:13])=[O:12].[K+]>S(=O)(=O)(O)O>[Cl:1][C:2]1[CH:9]=[C:8]([F:10])[C:7]([N+:11]([O-:13])=[O:12])=[CH:6][C:3]=1[CH:4]=[O:5]参加物
4
反応条件
- 温度
- 0 °C
実験手順
A stirred solution of 2-chloro-4-fluorobenzaldehyde (1.0 g, 6.3 mmol) in conc. sulphuric acid (8 ml) at 0° C. under argon was treated portionwise with potassium nitrate (0.70 g, 6.9 mmol) and maintained at 0° C. for 30 minutes, before warming to room temperature over 1.5 hrs. The reaction mixture was added to well stirred ice/water (100 ml) and then extracted with ethyl acetate. The extract was dried and concentrated to leave the title compound as a pale yellow oil (1.15 g, 90%).
後処理
- temperaturebefore warming to room temperature over 1.5 hrs
- extractionextracted with ethyl acetate
- customThe extract was dried
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-be49743bd7ff485f98a6c0651a56c04f
- 出典データセット
- uspto-grants-2012_10
- 特許番号
- US08288412B2
反応ノート
読み込み中…