N,N-Dimethylaniline → HCID 25259881、化合物

HRID 2064569ノート

反応式

HRID 2064569 の反応式
[F:1][C:2]([F:25])([F:24])[C:3]1[CH:4]=[C:5]([CH:9]([O:13][C:14]2[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=CN=2)[C:10]([OH:12])=[O:11])[CH:6]=[CH:7][CH:8]=1.[CH3:26][N:27](C)C1C=CC=CC=1.O1[CH2:40][CH2:39][N:38]([CH:41](O)[CH3:42])[CH2:37][CH2:36]1.[OH2:44]>O1CCCC1.CCOCC>[N:38]1([CH2:41][CH2:42][O:12][C:10](=[O:11])[CH:9]([C:5]2[CH:6]=[CH:7][CH:8]=[C:3]([C:2]([F:1])([F:25])[F:24])[CH:4]=2)[O:13][C:14]2[CH:26]=[N:27][C:17]([C:20]([F:21])([F:22])[F:23])=[CH:18][CH:19]=2)[CH2:39][CH2:40][O:44][CH2:36][CH2:37]1

参加物

7

反応物 4

HCID 949N,N-DimethylanilineHCID 962WaterHCID 30293761-MorpholinoethanolHCID 25259649(3-Trifluoromethyl-phenyl)-(5-trifluoromethyl-pyridin-2-yloxy)-acetic acid

生成物 1

HCID 25259881HCID 25259881、化合物

試薬・触媒・溶媒 2

HCID 3283Diethyl Ether溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

(3-Trifluoromethyl-phenyl)-(5-trifluoromethyl-pyridin-2-yloxy)-acetic acid, 100, prepared as described in Example 4, (0.05 mol) was converted into the acid chloride, using the procedure of Example 6. The acid chloride (0.01 mol) was dissolved in tetrahydrofuran (25 mL) and N,N-dimethylaniline (2 mL) and morpholinoethanol (2 mL) were added. The progress of the reaction was monitored by TLC. When the reaction was complete, water and ether were added. The organic phase was washed with dilute hydrochloric acid, dried and concentrated. The residue was chromatographed to afford the title compound 137.

後処理

  1. washThe organic phase was washed with dilute hydrochloric acid
  2. customdried
  3. concentrationconcentrated
  4. customThe residue was chromatographed

出典と根拠

ORDレコード
ord-a5e56f69397041739a93f9299d13f4f5
出典データセット
uspto-grants-2012_10
特許番号
US08288438B2

反応ノート

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