1H-Indazol-3-ylmethanol → HCID 178520025、化合物

HRID 2064571

反応式

HRID 2064571 の反応式
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([CH2:10][OH:11])=[N:2]1>COCCOC.[O-2].[O-2].[Mn+4]>[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([CH:10]=[O:11])=[N:2]1

参加物

4

反応物 1

HCID 1785200261H-Indazol-3-ylmethanol

生成物 1

HCID 178520025HCID 178520025、化合物収率 90.2%

試薬・触媒・溶媒 2

HCID 178418406HCID 178418406、化合物触媒HCID 80711,2-Dimethoxyethane溶媒

反応条件

温度
20 °C

実験手順

A solution of 2.27 g of (1H-indazol-3-yl)methanol in 220 ml of 1,2-dimethoxyethane is added to 13.32 g of manganese dioxide. After one hour at a temperature in the region of 20° C., the reaction mixture is refluxed for 15 minutes. After cooling to a temperature in the region of 20° C., the reaction medium is filtered through a sinter funnel packed with Celite. The collected filtrate is concentrated under reduced pressure at a temperature in the region of 40° C. 2.02 g of 1H-indazole-3-carboxaldehyde are thus obtained in the form of a yellow powder, the characteristics of which are as follows:

後処理

  1. temperaturethe reaction mixture is refluxed for 15 minutes
  2. filtrationthe reaction medium is filtered through a sinter funnel
  3. concentrationThe collected filtrate is concentrated under reduced pressure at a temperature in the region of 40° C

出典と根拠

ORDレコード
ord-92e718e1225b4f5b84e6107ab8c77e91
出典データセット
uspto-grants-2012_10
特許番号
US08288425B2

関連ノート

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