6-Chloroimidazo[2,1-b][1,3]thiazole-5-carbaldehyde → 6-Chloroimidazo[2,1-b][1,3]thiazole-5-carboxylic acid

HRID 2064749ノート

反応式

HRID 2064749 の反応式
[O-:1]Cl.[Na+].[Cl:4][C:5]1[N:6]=[C:7]2[N:11]([C:12]=1[CH:13]=[O:14])[CH:10]=[CH:9][S:8]2>O.C(O)(C)(C)C>[Cl:4][C:5]1[N:6]=[C:7]2[N:11]([C:12]=1[C:13]([OH:1])=[O:14])[CH:10]=[CH:9][S:8]2

参加物

5

反応物 2

HCID 3299506-Chloroimidazo[2,1-b][1,3]thiazole-5-carbaldehydeHCID 23665760Sodium Hypochlorite

生成物 1

HCID 3299776-Chloroimidazo[2,1-b][1,3]thiazole-5-carboxylic acid

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6386tert-Butanol溶媒

実験手順

A solution of NaOCl (230 mmol) and NaH2PO4 (176 mmol) in water (195 mL) is added dropwise to a solution of 6-chloro-imidazo[2,1-b]thiazole-5-carbaldehyde (26.8 mmol) in tert.-butanol (195 mL) and the mixture is stirred for 8 h at RT. The solvents are partially removed in vacuo and the obtained precipitate is filtered off. The filtrate is made acidic and the obtained precipitate is filtered off to give the desired product as a white solid. LC-MS: tR=0.67 min; [M+H]+=202.9.

後処理

  1. customThe solvents are partially removed in vacuo
  2. filtrationthe obtained precipitate is filtered off
  3. filtrationthe obtained precipitate is filtered off

出典と根拠

ORDレコード
ord-f8a3397c310d4681ac1b2a38b5f3b71a
出典データセット
uspto-grants-2012_10
特許番号
US08288435B2

反応ノート

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