Sodium Hydroxide → Pyrrolo[2,1-b][1,3]thiazole-7-carboxylic acid
反応式
C([O:3][C:4]([C:6]1[CH:7]=[CH:8][N:9]2[CH:13]=[CH:12][S:11][C:10]=12)=[O:5])C.[OH-].[Na+]>CO.O>[S:11]1[CH:12]=[CH:13][N:9]2[CH:8]=[CH:7][C:6]([C:4]([OH:5])=[O:3])=[C:10]12参加物
5
反応条件
- 温度
- 55 °C
実験手順
A mixture of pyrrolo[2,1-b]thiazole-7-carboxylic acid ethyl ester (5.12 mmol) and sodium hydroxide (7.68 mmol) in MeOH (5.8 mL) and water (5.8 mL) is heated to 55° C. for 23 h. The mixture is concentrated in vacuo and made acidic by addition of hydrochloric acid (1.0 M). The obtained precipitate is filtered off and dried in vacuo to give the desired product. LC-MS: tR=0.87 min; [M+H]+=168.0.
後処理
- concentrationThe mixture is concentrated in vacuo
- additionmade acidic by addition of hydrochloric acid (1.0 M)
- filtrationThe obtained precipitate is filtered off
- customdried in vacuo
出典と根拠
- ORDレコード
- ord-fc676d513fd94280b75ad5668ca4eff5
- 出典データセット
- uspto-grants-2012_10
- 特許番号
- US08288435B2
反応ノート
読み込み中…