Trifluoroacetic acid → 3-(Hydroxymethyl)azetidine trifluoroacetate
反応式
[OH:1][CH2:2][CH:3]1[CH2:6][N:5](C(OC(C)(C)C)=O)[CH2:4]1.[F:14][C:15]([F:20])([F:19])[C:16]([OH:18])=[O:17]>>[F:14][C:15]([F:20])([F:19])[C:16]([OH:18])=[O:17].[OH:1][CH2:2][CH:3]1[CH2:6][NH:5][CH2:4]1参加物
3
実験手順
To tert-butyl 3-(hydroxymethyl)azetidine-1-carboxylate (125 mg) was added trifluoroacetic acid (0.413 ml) while cooling in an ice bath, followed by stirring at the same temperature for 30 min. Then, the reaction mixture was stirred at room temperature for 1.5 hr. The reaction mixture was concentrated to provide a crude product of the titled compound as a yellow oil (209.8 mg).
後処理
- temperaturewhile cooling in an ice bath
- stirringThen, the reaction mixture was stirred at room temperature for 1.5 hr
- concentrationThe reaction mixture was concentrated
出典と根拠
- ORDレコード
- ord-f55fba82ad1e4096990f4d9d723f1410
- 出典データセット
- uspto-grants-2012_10
- 特許番号
- US08288538B2
反応ノート
読み込み中…