Triethylamine → HCID 58117145、化合物
反応式
FC(F)(F)C(O)=O.[CH:8]12[NH:15][CH:12]([CH2:13][CH2:14]1)[CH2:11][N:10]([C:16](=[O:21])[C:17]([F:20])([F:19])[F:18])[CH2:9]2.C(N(CC)CC)C.Br[CH2:30][C:31]1[S:39][C:38]2[C:37]([N:40]3[CH2:45][CH2:44][O:43][CH2:42][CH2:41]3)=[N:36][C:35]([Cl:46])=[N:34][C:33]=2[CH:32]=1>C1COCC1>[Cl:46][C:35]1[N:36]=[C:37]([N:40]2[CH2:41][CH2:42][O:43][CH2:44][CH2:45]2)[C:38]2[S:39][C:31]([CH2:30][N:15]3[CH:8]4[CH2:14][CH2:13][CH:12]3[CH2:11][N:10]([C:16](=[O:21])[C:17]([F:18])([F:19])[F:20])[CH2:9]4)=[CH:32][C:33]=2[N:34]=1参加物
5
実験手順
To a solution of 1-(3,8-diaza-bicyclo[3.2.1]oct-3-yl)-2,2,2-trifluoro-ethanone trifluoroacetic acid salt (106 mg, 0.33 mmol) in THF (5 mL) were added triethylamine (161 μL, 1.16 mmol) and 6-bromomethyl-2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (100 mg, 0.29 mmol). The reaction mixture was stirred at RT for 17 h, then concentrated in vacuo. The resultant residue was purified by column chromatography to give the title compound as a white solid (98 mg, 71%).