Trifluoroacetic acid → (9aR)-Hexahydropyrazino[2,1-c][1,4]oxazin-4(3H)-one
反応式
C(OC([N:8]1[CH2:17][CH2:16][N:15]2[C@@H:10]([CH2:11][O:12][CH2:13][C:14]2=[O:18])[CH2:9]1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH2:11]1[C@H:10]2[CH2:9][NH:8][CH2:17][CH2:16][N:15]2[C:14](=[O:18])[CH2:13][O:12]1参加物
4
実験手順
To a solution of (R)-4-oxo-hexahydro-pyrazino[2,1-c][1,4]oxazine-8-carboxylic acid tert-butyl ester in DCM (5 mL) was added TFA (1 mL). The resulting mixture was stirred at RT for 2 h then concentrated in vacuo. The resulting residue was azeotroped with toluene then purified by SCX column to give the title compound as a colourless oil (60 mg, 76%).
後処理
- concentrationthen concentrated in vacuo
- customThe resulting residue was azeotroped with toluene
- customthen purified by SCX column
出典と根拠
- ORDレコード
- ord-982ec4c61c4247c188d73c7fc6dbefaf
- 出典データセット
- uspto-grants-2012_10
- 特許番号
- US08293735B2
反応ノート
読み込み中…